Power enhancement via multivariate outlier testing with gene expression arrays

Power enhancement via multivariate outlier testing with gene expression arrays

MOTIVATION As the use of microarrays in human studies continues to increase, stringent quality assurance is necessary to ensure accurate experimental interpretation. We present a formal approach for microarray quality assessment that is based on dimension reduction of established measures of signal and noise components of expression followed by parametric multivariate outlier testing. RESULTS...

General nonlinear framework for the analysis of gene interaction via multivariate expression arrays.

A cDNA microarray is a complex biochemical-optical system whose purpose is the simultaneous measurement of gene expression for thousands of genes. In this paper we propose a general statistical approach to finding associations between the expression patterns of genes via the coefficient of determination. This coefficient measures the degree to which the transcriptional levels of an observed gen...

Precise Gene Expression Measurement with Outlier Detection

Outlier Detection in Multivariate Time Series via Projection Pursuit

This article uses Projection Pursuit methods to develop a procedure for detecting outliers in a multivariate time series. We show that testing for outliers in some projection directions could be more powerful than testing the multivariate series directly. The optimal directions for detecting outliers are found by numerical optimization of the kurtosis coefficient of the projected series. We pro...

Multivariate Feature Extraction for Prediction of Future Gene Expression Profile

Introduction: The features of a cell can be extracted from its gene expression profile. If the gene expression profiles of future descendant cells are predicted, the features of the future cells are also predicted. The objective of this study was to design an artificial neural network to predict gene expression profiles of descendant cells that will be generated by division/differentiation of h...